Why Was Harriet Tubman One Of The Most Famous Conductors

Questions: Notes: Why did states secede? What was the importance of popular sovereignty? What was the underground railroad used for? Why was Harriet Tubman one of the most famous conductors? What was Harriet Beecher Stowe famous for? Why was Franklin Pierce important? What was the Dred Scott case and why was it important? What were Stephen Douglas’ beliefs? What were Abraham Lincolns’ beliefs and what was his lasting impression? What was the confederacy? Who was Jefferson Davis and what was his role in the Confederacy? States used this technique of withdrawing from the Union when they disagreed with the Union or used it as a threat to get what they wanted. This was an important provision that allowed the right to vote for slavery or not. It was used in the Compromise of 1850 to make both sides happy. It was the secret tunnels and passageways that slaves used to escape. People on these railroads hid slaves, giving them food and shelter. She was one of the conductors, or people who helped slaves escape through the Underground Railroad and was an important figure who successfully escaped slavery herself. The famous author of Uncle Tom’s Cabin about the struggles of slavery. This book was significant because it inspired more Northerners against the Fugitive Slave Act. He was a democratic candidate of the North who won and produced the Kansas-Nebraska Act that became the downfall of the Southern Whigs. It was about a slaveShow MoreRelatedThe Underground Railroad Is Not Like The Railroad1387 Words   |  6 Pagesor to Mexico, or the Caribbean Islands where slavery is illegal. This was an impossible task for the slaves to do on their own. There were many factors on how they found their way and the people who helped them on their journey, which I will discuss later throughout this paper. There over 3000 people who helped the runaway slaves to freedom. (The Underground Railroad). There are a few that stand out in history: Harriett Tubman, Levi and Catharine Coffin, William Still, John and Jean Rankin, and CaptainRead MoreThe Underground Railroad2038 Words   |  9 PagesThe Underground Railroad was the name of the network that was used by enslaved African Americans. It consisted of very intricate routes that were used so that those moving along its path could lose pursuers traveling under the guise of darkness and staying in safe houses during the day. The goal of the railroad was to get the slaves from the South to the Free states and to Canada where slavery was prohibited. A slave knew that once they crossed the border into any one of the Free states that theyRead MoreSlavery And The Slave Owners1419 Words   |  6 PagesSlaves; people who are the property of and wholly subject to another. Why did it begin in the first place? It was not until December 6th of 1865 when congress finally ratified a law to abolish slavery. However, words of the law still had not spread and it would take around a year for the slave owners to finally set the slaves free. The process of freeing the slaves was full of misery, pain, and constant insults by the majority of the white population. However, despite discouragement from the whitesRead MoreBlacks During The Early 1800s Essay1635 Words   |  7 Pagesrestrictions and laws because of their status in society. In the early 1830s, a law in Virginia was made to prohibit all blacks from getting their education. They even took it to the level where free blacks who went out of state to educate themselves were not able to come back and return to their own state. The worst restriction was that blacks could not testify in court. When a slave owner claimed that a free black was their slave, they could not defend themselves, and would have to conform back to theirRead MoreHarriet Tubman And The Underground Railroad1965 Words   |  8 PagesKeywords Notes What happened to the Southern secession? There was a distress on the border dispute where Texas claimed the eastern half of the New Mexico Territory where slavery issues were still not settled. As desires attached, there were threats in the Southern secession more frequently. Secession- the formal withdrawal of a state from the Union What did the popular sovereignty help? Clay made a compromise that had necessities to placate Northerners and also southerners. North- providedRead MoreInevitable or Avoidable: The American Civil War1877 Words   |  8 Pages The biggest war that ever happened was the Civil War. This was the most deadliest, and hurtful wars between the North and the South. This war lasted for four years straight from 1861 to 1865. So many events led up to this war which made it so brutal. I believe that the events that took place to start the civil war could have been easily avoided by just a little communication that they did not use around that time. I do not believe everything that happened in those four years should have happenedRead MoreEssay on underground railroad1680 Words   |  7 Pagesremains a mystery to many as to exactly when it started and why. (Carrasco). The Underground Railroad is known by many as one of the earliest parts of the antislavery movement. Although the system was neither underground nor a railroad, it was a huge success that will never be forgotten. nbsp;nbsp;nbsp;nbsp;nbsp;I chose to research the Underground Railroad because I have heard so much about it, but my knowledge about the subject was very minimal. I found the Underground Railroad very interestingRead MoreSlavery in the South Essay868 Words   |  4 PagesSlavery in the South Slavery of the Black man in America was the cruelest ever known to man. Europeans transported slaves from Africa as early as 1505. The African Slaves were first exploited on an island named Hispaniola, in the Caribbean by the Europeans to do labor work, before they were sent to the Americas. The women usually worked the interior cooking and cleaning while the men were sent out into the plantation fields to farm. These Africans were stripped of their homes, cultures, andRead MoreSummary Of Uncle Tom s Cabin 2027 Words   |  9 Pagesstate. This was the government’s attempt to satisfy both the North and the South. What is the Underground Railroad? The Underground Railroad was a secret â€Å"railroad system† created by abolitionists to hide runaway slaves. Who is Harriet Tubman and what is her significance? Harriet Tubman was a famous â€Å"conductor† of the Underground Railroad. She travelled back to the south 19 times and helped around 300 slaves, two of them being her own parents. Who is Harriet Beecher Stowe? Harriet Beecher StoweRead MoreThe Divisive Politics Of Slavery2638 Words   |  11 PagesTopic: 4.1 The Divisive Politics of Slavery Date: 8/18/15 Questions/ Cues: Notes: What caused secession in the South? Why do you think that popular sovereignty was created? Describe what the Underground Railroad was? Who was Harriet Tubman? How did Harriet Beecher Stowe work to resolve slavery? Why do you think that Franklin Pierce’s democratic victory was important? Can you explain the case of Dred Scott? How did Stephen Douglas believe slavery should be stopped?

Reflection On My Life Experiences - 959 Words

Woods. Session1. Journal Reflection Lesson HEART/HAND/HEAD Everything in life happens for a reason and nothing happens by happenstance, chance or luck. I believe our life experiences can bring us many different learning opportunities if taken. Which can bring about a great wisdom and knowledge to help oneself or others in life. The Heart, Hand, Head are all very vital parts of the body both Naturally Spiritually and without these organs or parts we would not be able to survive. Starting with the â€Å"Heart† spiritually it brings about love, trust, forgiveness, honesty, and conviction (Example) John 3:16 â€Å"For God so loved the world he gave his only begotten son, for whom so ever believeth in him should not perish, but have everlasting life†. Naturally without a heart one cannot breathe or function at all and would be an empty shell for one cannot operate or function without it. My transformation began about 12 years ago. Now isn’t that interesting a preacher’s daughter who was born and raised into ministry wasn’t truly transformed until my late twenties â€Å"Odd†? Maybe (or) maybe not! Because of my own stubbornness and pride I went through about 8-9 years of trials and tribulations brought upon myself. Now, don’t get me wrong I was exceling in life at work, business ownership and socially. I thought I had it all and that I was responsible for it all as I soon realized â€Å"NOT SO†. Once things became tough in life and the feeling of emptiness and the void became so intense too intenseShow MoreRelatedMy Reflection On Life And My Experiences In My Life1515 Words   |  7 Pageswere always curious about my past experience and my outlook on life. With everything in life going fast paced, I never had that chance to fulfill that curiosity. At the moment, I am taking a sociology class which makes me look at my life from a sociological standpoint and I want to share with you some of my experiences and how it is influenced by society. Growing up, I was born to a working lower-class family, where my parents did their best to make end meets. My parents struggle to enrollRead MoreReflection on Action1452 Words   |  6 PagesReflection on action Introduction Reflection now a days is very important in health practises as it allows the practitioners to gain understandings from their professional and personal experiences .It has proven to be an essential utensil for development in their area. Reflection is seen as an influential resource of seeing accustomed events as fresh and inspiring. It is a way for critical thinking and learning. Thinkers have warned of the dangers of a life spent without reflection, but whatRead MoreErik Erikson s Psychosocial Development1629 Words   |  7 PagesReflection Paper #4 Erik Erikson’s psychosocial stages theory suggests that people pass through eight distinctive developmental stages as they grow and change throughout their lives. Integrity versus despair is the eighth and final stage of Erikson’s stage theory of psychosocial development. This stage begins at approximately age 60 and ends at death. The crisis represented by this last life stage is integrity versus despair. Erikson proposed that this stage begins when the individual experiencesRead MorePRS Coursework 11224 Words   |  5 Pages160: PERSONAL AND RESEARCH SKILLS (FULL TIME) MOIRA BAILEY 1415792 CINDY OMARI WORD COUNT: 1,051 This reflective paper aims at analyzing my learning experience in the Personal and Research Skills module and how these experiences are likely to help both my post graduate study at The Robert Gordon University and my future career. During my post graduate studies at The Robert Gordon University, Aberdeen, Personal and Research Skills was one of the four modules I took in the first semesterRead MoreReflection On A Teaching Strategy882 Words   |  4 PagesReflection is not a teaching strategy that is usually associated with a mathematics classroom. I have taught mathematics to 8th grade students for the last six years; in my time as a teacher I have found that most of my students are not able to reflect and make the connections that their grade in my class is linked to their actions in class. Similar to most teachers, at the end of a semester I have several students that want extra credit to improve their grade last minute. These are the same studentsRead Morecomparing relevant theories principles and models of reflective practice965 Words   |  4 Pagesreflective practice and explain how they relate to my practice and development. Reflective practice is an evolving concept. In the 1930s, John Dewey defined reflective thought as: ‘Active, persistent, and careful consideration of any belief or supposed form of knowledge in the light of the grounds that support it and the further conclusions to which it tends.’ He set out five phases or aspects through which we can see a process of reflection. However using phrases such as phase and stageRead MoreReflection Of A Reflective Leadership Retreats1084 Words   |  5 Pagesother about things that are important†¦individually and collectively† (p. 22) Reflection on Retreat Experience Accustomed to a world inundated with technology, constant motion, and noise, spending a sustained period of time in nature initially produced feelings of isolation and withdrawal. The feelings of detachment from smartphones and social media were palpable. Eventually, I began acclimating to the serenity of my surroundings. The chirping of the birds, blowing of the wind, and quacking of theRead MoreReflection On Oppression707 Words   |  3 Pagesissue in my own life that I needed to face that lead from reflection to action was an abusive relationship. Linked to the spiral model of learning the first step taken by myself was identifying i belonged to an oppressed group. Admitting both the situation, along with belonging to a group of oppression was extremely challenging for me. To overcome these issues I needed to reflect on it. Once again, this is challenging, as reliving it is hard, and being honest with oneself is hard. During my reflectionRead MoreLessons Learned Paper1448 Words à ‚  |  6 Pagesmotivated me to endure in my program. There were several eye-openers that revealed development and improvement as a doctoral student. In the last five days, various lessons and experiences were taught and learned but the most important lessons for me include the learning team experiences, scholarly writing, and reflection on the lessons learned. Learning Teams During this residency experience, I acquired a lot about learning teams. In my academic and professional experience, I have been a part ofRead MoreTeaching Skills As A Human Resource Practice Student1002 Words   |  5 Pagesanyone’s entire life and it is therefore a set of transferrable skills. Thus study skills are very essential to complete my HRP degree as well as throughout my life. In my own personal point of view, I will develop ways to study and learn in a way that will meet my own necessities. When I will be building up my skills, I would be able to find out what is working for me and what isn’t. I will have to understand the concepts, theories and ideas that are much more appropriate for my level 4 and level

Essay on Science and Religion - 2169 Words

Humans do not engage the world in a neutral way. Instead, we see world through the reality that our culture creates. Without culture, humanity would have to continuously reinvent the wheel, perhaps even literally. It casts a web of reality over us that is inescapable. We are constantly in the grip of our culture. Therefore, it isn’t surprising to find societies with cultures which differ greatly from ours who come to very different conclusions about what reality is. When we are confronted with these differences in world views, we are often quick and confident to assert that our way of life is superior to others. This is behavior isn’t unique to tribes indigenous to foreign lands who believe in so-called â€Å"primitive† religions. It†¦show more content†¦Every part of it depends upon the existence of witchcraft, just as their absolute belief in witchcraft depends upon the rest of their cultural framework. There is a system of self-reinforcement, which causes the belief to go unquestioned, even when the effects are inconsistent with an objective reality. Evans-Pritchard explains, â€Å"Azande do not perceive the contradiction as we perceive it because they have no theoretical interest in the subject, and those situations in which they express their beliefs in witchcraft do not force the problem upon them.†(Evans-Pritchard, 25) Even if one is able to point out the inconsistent effects of witchcraft, the Azande will not believe it, but in fact will find a way to incorporate inconsistencies into his worldview, Evans-Pritchard tells us. However, he also points out that, â€Å"they did not attempt to account for the existence of phenomena, or even the action of phenomena, by mystical causation alone†(Evans-Pritchard, 67) and that â€Å"They reason excellently within the idiom of their beliefs†(Evans-Pritchard,XX), and thus are not mentally inferior or irrational. They merely engage the world through a dif ferent idiom than the Westerner. However, if the Azande are blinded by their beliefs in witchcraft, we cannot be sure that we are free from the same sort of cultural blinders. Just as the Azande are at the mercy of witches, oracles, and sorcerers,Show MoreRelatedRelationship Between Science And Religion Essay2131 Words   |  9 PagesThe relationship between science and religion as Western categories of thought has long been fraught with tension; academics suggest that the conflict between religion and science arose in the 17th century, as a result of the Galileo Affair, and continued into the 18th century Age of Enlightenment. Others, however, suggest that the dispute between the two systems of belief may even be traced as far back as classical antiquity. Even today, it is clear that tensions endure between academics unableRead MoreReligion and Science Need Each Other935 Words   |  4 Pagesâ€Å"Science without religion is lame, religion without science is blind.† Thi s famous quote was spoken by a man even more famous for his scientific works in the fields of physics and mathematics. Albert Einstein, famous scientist, is found here stating that without religion science is, essentially, useless. Surely it is impossible for a man so accomplished in the scientific field to seriously consider the possibility of God? Certainly, we live in a time where there has been much condemnation and ridiculeRead MoreLife of Pi: the Correlation Between Science and Religion Essay1582 Words   |  7 PagesMs. Ciufo ENG-3U1 Wednesday, April, 28, 2010 Life of Pi: Correlation between Science and Religion One of the most important dichotomies that exist amongst today is Science versus Religion. A dichotomy that started in the renaissance era, a period when people started questioning, looking to other horizons, other than religion and truly began to comprehend reality. The theme of Science versus Religion is portrayed in a great deal in the novel Life of Pi. In Life of Pi, Yann Martle utilizesRead MoreReligion : Science And Religion1273 Words   |  6 PagesScience and religion were based back in modern days to be the answer to everyone, and society as a whole to handle their issues through the church majority of the time, until science came along and changed the perspective of everyone’s outlook on how they were to solve their conflicts. Within the world today they both still exist and are still being put to use for its main purpose which is to create answers to things we face that need a solution. I believe Religion started inRead MoreScience And Religion755 Words   |  4 PagesAre science and religion related? If so, how are they related? What is the importance of them in human lives? I believe, science and religion are related to each other. The relationship between them has been debated for several years. Science is linked to the material, while religion is worried about spirituality (Vikas, 2012). Humans depend on both religion and science not one or the other. In spite of being different from each other, science and religion are related and linked to each other. ScienceRead MoreQuestions On Religion Of Science925 Words   |  4 PagesCONCLUSION Religion of Science Ernest Holmes asks us to consider three general classifications of knowledge: 1. Science: â€Å"†¦ the organized knowledge of natural law and its application to life.† 2. Philosophy: â€Å"†¦ the opinions one holds about the world, life, and reality.† 3. Religion: â€Å"†¦ any man’s belief about his relationship to the invisible universe.† â€Å"We might speak of a pure religious science as we would speak of a pure natural science, which means the study of natural causes. We might speakRead MoreThe Between Religion And Science810 Words   |  4 PagesAll that I have ever known and believed in is now being questioned. It is transitioning into some sort of enormous trial – between religion and science. I have been taught to accept the religious, social, and political ideas that the Catholic Church has devised upon the world. For years, humans have believed and used Aristotle’s theory which explained Earth’s position in the universe. By the geocentric theory, Earth was said to be located at the center of the universe. The moon, the sun, and theRead MoreInfluence Of Science And Religion1564 Words   |  7 Pages1. Q) Compare and contrast the influence of science and religion in the development of humanity. Discuss both the positive and the negative. A) The systematic testing of observations, and the belief of something larger than ourselves, have been part of the human experience since time began. Both science and religion have influenced human thought and civilization. When a question could not be answered by time and observation, people fell back on spiritual explanationsRead MoreScience and Religion Essays808 Words   |  4 PagesScience and religion have always been in conflict with one another because they each represent complete opposite ideals, science is about how nature controls how the universe works and religion is about how God controls how the universe works. In the five models on science and religion I believe that Conflict best describes the relationship between the two. Conflict tells how either science is completely right and religion is wrong or the other way around and that religion and science are completelyRead MoreEvolution Of Science And Religion1179 Words   |  5 PagesWhen comparing science and reli gion there has been a great rift. As long as humanity has believed in a creator there as always been thinkers trying to quantify and evaluate the truth behind religion, trying to disprove or prove a supernatural force. The ancient Greeks were pioneering philosophers which started the great rift we see in the early development of scientific and quantified analysis. This was first started by Aristotle whuch believed that science was a process of trying to understand

The Arctic Of The Antarctic Circle - 1716 Words

Any point north of the Arctic Circle or south of the Antarctic Circle will have one period in the summer when the sun does not set, and one period in the winter when the sun does not rise. At progressively higher latitudes, the maximum periods of midnight sun and polar night are progressively longer. For example, at the military and weather station Alert located at 82 °30†²05†³N and 62 °20†²20†³W, on the northern tip of Ellesmere Island, Canada (about 450 nautical miles or 830 km from the North Pole), the sun begins to peek above the horizon for minutes per day at the end of February and each day it climbs higher and stays up longer; by 21 March, the sun is up for over 12 hours. On 6 April the sun rises at 0522 UTC and remains above the horizon until it sets below the horizon again on 6 September at 0335 UTC. By October 13 the sun is above the horizon for only 1 hour 30 minutes and on October 14 it does not rise above the horizon at all and remains below the horizon until it rises again on 27 February.[17] First light comes in late January because the sky has twilight, being a glow on the horizon, for increasing hours each day, for more than a month before the sun first appears with its disc above the horizon. From mid-November to mid-January, there is no twilight. In the weeks surrounding 21 June, in the northern polar region, the sun is at its highest elevation, appearing to circle the sky there without going below the horizon. Eventually, it does go below the horizon,Show MoreRelatedGlobal Warming Reflection Paper1510 Words   |  7 Pageshave a greener earth and slow the global warming. Environmental and social implications regarding climate changes Climate changes are affecting the earth worldwide. According to Arctic Melt Unnerves the Experts article â€Å"The Arctic ice cap shrank so much this summer that waves briefly lapped along two long-imagined Arctic shipping routes, the Northwest Passage over Canada and the Northern Sea Route over Russia† (NY Times, 2007). Ice glaciers are melting and sea levels are increasing. The climate changeRead MoreThe Negative Effect of Global Warming892 Words   |  4 Pagesmountain glaciers, Arctic sea ice, and ice sheets covering West Antarctica and Greenland (Global Warming Puts the Arctic on Thin Ice). When the large blocks of ice start to melt, the ability to reflect sunlight is lost. Usually when sunlight hits the polar ice caps, it is reflected back into space (Global Warming Puts the Arctic on Thin Ice). Without the ability, the ocean absorbs the sunlight and heats up ocean water (Global Warming Puts the Arctic on Thin Ice). This is how Arctic temperatures continueRead MoreClim ate Change1617 Words   |  7 PagesThe deterioration in Arctic sea ice, both in magnitude and width, over the last numerous decades is additional evidence for rapid climate change. Sea ice is frozen seawater that drifts on the ocean surface. It overlays millions of square kilometers in the Polar Regions, fluctuating with the seasons. In the Arctic, some sea ice remains year after year, although almost all Southern Ocean or Antarctic sea ice melts away and reforms annually. Satellite surveillances show that Arctic sea ice is now deterioratingRead MoreGlobal Warming Is The Main Features Of Climate Change921 Words   |  4 Pagessalinization, etc., resulting in natural ecological environment imbalances, the coastal, estuary, bay to the coastal zone of ecological environment system disaster. Global climate change, climate warming, rising temperatures may lead to the Antarctic Peninsula and the arctic melt, and influence polar bear and walrus survival environment. Global climate change will lead to human health is at risk. Scientific research shows that as the climate warming, some harmful substances in the air, such as fungal sporesRead MoreThe Density Of Jupiter1293 Words   |  6 Pageshigher in the sky. This results in warmer average temperatures, as additional solar radiation reaches the surface. When the north pole is tilted away from the Sun, the reverse is true and the weather is generally cooler. Above the Arctic Circle and below the Antarctic Circle, an extreme case is reached in which there is no daylight at all for part of the year. This is called a polar night. This variation in the weather (because of the direction of the Earths axial tilt) results in the seasons. TheRead MoreGlobal Warming : Fact Or Fiction? Essay1395 Words   |  6 Pagesearth has undergone at least five different ice ages, in addition to various heating cycles. The man himself has never been at the forefront of any of these causes. Currently, the earth is in the middle of one of its heating cycles which will probably circle back again to a cooling cycle. In fact, it was not more than sixty years ago when the academic world was advocating for climate change due to â€Å"global cooling,† rather than global warming. This is further evidence for a cyclical climate rather thanRead MoreDiscussion of a biome using specific information about precipitation patterns, plants, animals, and general locations 1356 Words   |  6 Pagesreceive extreme temperatures of 43-49 °C during day and usually have very little rainfall and/or concentrated rainfall in short periods between long rainless periods, averaging about 250 mm of rain per year. The cold deserts are situated near the Arctic Circle and are mostly covered in snow, but can receive rainfall during spring(usually around 15-26 cm per year). Temperatures range from -2 to 26 °C. Contrary to popular belief, deserts have usually high biodiversity. Both the flora and fauna are adaptedRead MoreA Study On The Killer Whales2384 Words   |  10 Pagesthe killer whales to justify breeding killer whales and keeping them in marine parks. Killer Whales are the largest member of the dolphin family and they found all over the world but in the largest quantities in the colder water of the Arctic and Antarctic. They have also been reportedly sighted in the warmer waters of the tropics and off the southern coasts of the United States (â€Å"Welcome†). Male killer whales can weigh up to 22,000 pounds and females killer whales can weigh up to 16,500 poundsRead MoreThe Building Sector Affects The Society2927 Words   |  12 Pagesdegrees. KurowskI (2014) also states that during the summer solstice the sun is directly overhead (90 degrees) at the Tropic of Cancer and has an angle of 66.5 at the Equator and is at the horizon at the Antarctic Circle (66.5 S). Below the Antarctic Circle, it is dark 24 hours a day. Above the Arctic Circle (66.6 N) there is sunlight 24 hours a day. Shaded surface For a shaded surface, the radiation incident falling on it varies based on the shading type. The difference in the shading type complicatesRead MoreClimate Change And The Global Warming2120 Words   |  9 Pagespresent climate change as â€Å"stronger than expected, sooner than forecast†. She drawn this conclusion from following aspects. Firstly, recent 30 or more years, The Arctic Ocean is losing sea ice. (Stroeve, Holland, Meir, Scambon Serreze, 2007) It means ocean water would be warmed more by the sun. And it would cause a vicious circle that the Arctic Ocean could be ice-free quickly during the summer, as well as difficult to form and to retain sea ice during the winter. According to a current forecast that

The hormone’s amino acid Free Essays

Insulin, an endocrine hormone, is one of the most well-studied proteins synthesized by the human body. Its relatively simple structure and short amino acid sequence have made it a useful model for many protein studies. It is synthesized in beta cells of the pancreas through posttranslational cleavage of proinsulin, and released upon stimulation by elevated levels of glucose in the blood. We will write a custom essay sample on The hormone’s amino acid or any similar topic only for you Order Now Insulin plays an important role in regulating several anabolic processes, and is most well-known for lowering the level of blood sugar by promoting the uptake and storage of glucose by the liver. Deficiency of, or resistance to insulin, results in either of the two forms of diabetes mellitus, a chronic metabolic disorder whose occurrence has increased among humans, especially in the United States; yet to this day, there is no definite cure for either form of the disease. Type II diabetes in particular must be treated with combinations of several different approaches, including dietary management, weight loss programs, and oral or antidiabetic drugs, or possibly surgical procedures such as gastric bypass. This proposal discusses the potential of taurine (2-amino ethanesulfonic acid), which had previously been tested in studies on rats and mice, to raise levels of insulin sensitivity in human subjects with insulin resistance, and raises the possibility that taurine could be used in a supplemental form for the treatment of diabetes mellitus type II patients. Introduction The endocrine hormone insulin was the first protein whose amino acid sequence was completed. For his work on deciphering its structure, Fred Sanger won the 1958 Noble Prize. Its discovery is considered a landmark, proving that proteins have a unique and defined sequence of amino acids, which has since been termed the primary structure. Since then, insulin has been used as a model for many subsequent studies regarding the structure and properties of various proteins. It is the human body’s major anabolic hormone, promoting reactions that lead to the uptake of glucose and its conversion into storage forms such as glycogen and triglycerides, while simultaneously inhibiting their breakdown for use as fuel. It also promotes the uptake of amino acids and the synthesis of proteins, promoting growth. Insulin was also the first protein to be synthesized using recombinant DNA in bacteria, and this technique has made possible the large scale production of supplemental insulin for use in one of the most serious metabolic diseases prevalent among humans, diabetes mellitus. The rising incidence of this disease, particularly in the United States, has drawn further interest into researching the intricacies of insulin and its role in regulating numerous anabolic body functions, as well as the various ways in which insulin’s functions can be regulated. Type II diabetes, the most common form of the disease, has no cure, and research is proceeding to look into several ways to increase sensitivity to insulin in insulin-resistant individuals suffering from this form of diabetes. In particular, taurine, a derivative of the amino acid cysteine, has shown a promising ability to potentially lower obesity and insulin resistance in rats and mice, although so far there have been few test studies on humans. Compared to other, more complex proteins, insulin is relatively small. It has a compact and monomeric structure (although it is capable of forming dimers or hexamers under certain conditions), with a molecular weight of roughly 6 kDa. The structure of active insulin is made up of two linked chains, labeled A and B, connected by two disulfide bonds, with a third disulfide bond linking the A chain back onto itself. This is a structure typical of the insulin family or group of proteins, which includes other peptide hormones such as relaxin, mammalian Leydig cell-specific insulin-like peptide, early placenta insulin-like peptide, and insulin-like growth factors I and II in humans. Evolutionarily related hormones belonging to this family have also been found in some insects and molluscs, and the nematode Caenorhabditis elegans. The hormone’s amino acid sequence (specifically, the sequence of the A and B chains) is conserved to such a degree that in most mammals, insulin extracted from another species remains biologically active. For instance, insulin from pigs and even bacteria, has been used to treat human patients suffering from diabetes mellitus. How to cite The hormone’s amino acid, Papers

Oedipus The King Free Will Vs Fate Persuasive Essay Example For Students

Oedipus The King: Free Will Vs Fate Persuasive Essay Oedipusthe King: Free Will vs FateThe events in Oedipus the King, writtenby Sophocles, show an underlying relationship of mans free will existingwithin the cosmic order or fate which the Greeks believed guided the universein a harmonious purpose. Man was free to choose and was ultimately heldresponsible for his own actions. Both the concept of fate and free willplayed an itregal part in Oedipus destruction. Although he was a victimof fate, he was not controlled by it. Oedipus was destined from birth tosomeday marry his mother and to murder his father. This prophecy, as warnedby the oracle of Apollo at Delphi was unconditional and inevitably wouldcome to pass, no matter what he may have done to avoid it. His past actionswere determined by fate, but what he did in Thebes, he did so of his ownwill. From the beginning of this tragedy, Oedipustook many actions leading to his own downfall. Oedipus could have waitedfor the plague to end, but out of compassion for his suffering people,he had Creon go to Delphi. When he learned of Apollos word, he could havecalmly investigated the murder of the former King Laius, but in his hastiness,he passionately curses the murderer, and in so, unknowingly curses himself. Upon the murderer I invoke this curse- whether he is one man and all unknown,or one of many- may he wear out his life in misery or doom! If with myknowledge he lives at my hearth, I pray that I myself may feel my curse.(pg. 438; lines 266-271)In order for Sophecles Greek audienceto relate to the tragic figure, he had to have some type of flaws or anerror of ways. This brought the character down to a human level, invokingin them the fear that it could happen to them. And Oedipus certainlyis not one without flaws. His pride, ingnorance, insolence and disbeliefin the gods, and unrelenting quest for the truth ultimately contributedto his destuction. When Oedipus was told (after threatening Teiresias),that he was responsible for the murder of Laius, he became enraged andcalls the old oracle a liar. He ran away from his home, Corinth, in hopesof outsmarting the gods divine will. Like his father, Oedipus also soughtways to escape the horrible destiny told by the oracle of Apollo. The chorus warns us of mans need to have reverence for the gods, and the dangersof too much pride. If a man walks with haughtiness of hand or word andgives no heed to Justice and the shrines of Gods despises- may an evildoom smite him for his ill-starred pride of heart!- if he reaps gains withoutjustice and will not hold from impiety and his fingers itch for untouchablethings. When such things are done, what man shall contrive to shield hissoul from the shafts of the God? (pg. 452; 975-984)Oedipus unyielding desire to uncover thetruth about Laius murder and the mystery surrounding his own birth, ledhim to the tragic realization of his horrific deeds. Teiresias, Jocastaand the herdsman tried to stop him from pursuing the truth. Take for examplea part of the last conversation between Jocasta and Oedipus. After realizingthat the prophecy had came true, Jacasta begs him to just let the mysterygo unsolved for once. I beg you- do not hunt this out- I beg you, if youhave any care for your own life. W hat I am suffering is enough. (pg. 461;1158-1161) Oedipus replies, I will not be persuaded to let chance of findingout the whole thing clearly. (pg. 461; 1166-1167) He is unable to stophis quest for the truth, even under his wifes pleading. For it is in hisown vain that he must solve the final riddle, the riddle of his own life. .ufb4ec97c4a06e58bbf3b7a7a189519b2 , .ufb4ec97c4a06e58bbf3b7a7a189519b2 .postImageUrl , .ufb4ec97c4a06e58bbf3b7a7a189519b2 .centered-text-area { min-height: 80px; position: relative; } .ufb4ec97c4a06e58bbf3b7a7a189519b2 , .ufb4ec97c4a06e58bbf3b7a7a189519b2:hover , .ufb4ec97c4a06e58bbf3b7a7a189519b2:visited , .ufb4ec97c4a06e58bbf3b7a7a189519b2:active { border:0!important; } .ufb4ec97c4a06e58bbf3b7a7a189519b2 .clearfix:after { content: ""; display: table; clear: both; } .ufb4ec97c4a06e58bbf3b7a7a189519b2 { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .ufb4ec97c4a06e58bbf3b7a7a189519b2:active , .ufb4ec97c4a06e58bbf3b7a7a189519b2:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .ufb4ec97c4a06e58bbf3b7a7a189519b2 .centered-text-area { width: 100%; position: relative ; } .ufb4ec97c4a06e58bbf3b7a7a189519b2 .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .ufb4ec97c4a06e58bbf3b7a7a189519b2 .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .ufb4ec97c4a06e58bbf3b7a7a189519b2 .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .ufb4ec97c4a06e58bbf3b7a7a189519b2:hover .ctaButton { background-color: #34495E!important; } .ufb4ec97c4a06e58bbf3b7a7a189519b2 .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .ufb4ec97c4a06e58bbf3b7a7a189519b2 .ufb4ec97c4a06e58bbf3b7a7a189519b2-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .ufb4ec97c4a06e58bbf3b7a7a189519b2:after { content: ""; display: block; clear: both; } READ: Procrastination of Hamlet EssayUpon discovery of the truth of his birthfrom the herdsman, Oedipus cries, I who first saw the light bred of amatch accursed, and accursed in my living with them, cursed in my killing.(pg. 465; 1300-1303) Oedipus knew that his fate had indeed come to passand feels cursed by it. The chorus then sings an ode on the sorrow of lifeand the tragic fate to which even the most honored, like Oedipus are ultimatelysubject. What man, what man on earth wins more happiness than a seemingand after that turning away? Oedipus you are my pattern of this, Oedipusyou and your fate! Luckless Oedipus, whom of all men I envied not at all. (pg. 465; 1305-1311)At the end of this tragic story, when Oedipusgouges out his eyes, the chorus asks him what god urged him to blind himself. Oedipus replied, It was Apollo, friends, Apollo, that brought this bitterbitterness, my sorrows to completion. But was the hand that struck me wasnone but my own. (pg. 467; 1450-1453) He claimed full responsibility forhis actions. Oedipus was guilty of killing his father and marrying hismother, but perhaps the true sin lay in his overzealous attempt to raisehimself to the level of the gods by trying to escape his fate. The choruschants about how in prosperity, he was envied by all men, he was honoredhighest above all honors, and how he won happiness by pride (by slaughteringthe Sphinx, and by trying to deceive the gods will.) But, how ultimately,Odipus was judged for it, causing a reversal of fortune in his prosperouslife. The fact that Oedpius motives for killinghis father, Laius, and wedding his mother, Jocasta, it does not take awayfrom the horrific nature of the crimes. When he tears at his eyes withhis Jocastas broach, Oedipus is accepting the full burden of his actsand knew that he must be punished for his sins. Therefore the last actof destruction was caused by Oedipus free will, but his tragic fate cameabout because of the nature of the cosmic order ( that every sin must bepunished) and role of the gods in human affairs. The chorus concludes this tragedy by warningthe Greeks, that the only way to happiness is through humility and respecttowards the gods, (qualities which Oedipus lacked, and ultimately led tohis destruction.) They also warn not to take anything for granted, or suffera fate like that of Oedipus. You live in my ancestral Thebes, beholdthis Oedipus,- him who knew the famous riddle and was a man most masterful,-not a citizen who did not look with envy on his lot-see him now and seethe breakers of misfortune swall him! Look upon that last day always. Countno mortal happy till he has passed the final limit of his life secure frompain. (pg. 470; 1643-1670)

Biotechnology Membrane Protein

Question: Describe about the Biotechnology for Membrane Protein. Answer: 1. As the G-coupled protein receptor are also an important class of membrane protein. Therefore the approach and technique that should be taken to determine the molecular structure of a particular G-coupled protein receptor is done by comparing the experimental mass date of the G-coupled protein receptor with the theoretical mass data that is generated from the previously predicted protein sequence. The homology comparison can very useful in this approach because it can identify the changes in the modification and the expression of the protein under different conditions. The techniques used for this approaches is at first the protein is separated by the process of 2D gel electrophoresis (Schaal et al. 2012). The 2D chromatography like the ion exchange chromatography and reverse phase high performance liquid chromatography (HPLC) can be more effective than the 2D gel in some cases such as the low abundance or hydrophobic proteins. Then the protein spot is to be cut from the gel and th en the protein is digested by different protease enzyme like trypsin. This digestion will generate a unique fragment pattern or finger print. After this mass spectroscopy is used for the analysis of this fragment. The mass spectroscopy will generate a protein specific mass finger print. To identify the protein the mass finger print of the protein which is tested is then matched with the predicted mass finger print of several proteins that are present in the protein sequence data bases (Sugimoto et al. 2012 pp.96-108). For this matching process many web based programs are available which assist the searching procedure of the sequence databases with the data of the mass spectrometry. The web based available programs that are present online are MS-Fit, Mascot ms/ms and Mascot PMF. The reason behind using the mass spectroscopy for the determining the molecular structure of the protein is that the results of the mass spectroscopy is very sensitive and accurate. The result of the mass spe ctroscopy is also very fast, these are the reason that mass spectroscopy has become the indispensable technique for the analysis of the biomolecules. Figure 1 Graph of Gel Electrophoresis Source: (Google.co.in, 2016) 2. The hormones are one type of protein and so if the researcher have to find which hormones are involved in causing the particular type of prostate cancer. The researcher have to understand the protein- protein interaction. To study protein-protein interaction several biophysical, genetic and biochemical experimental methods have been developed. For the understanding the protein-protein interaction that researcher can utilize is Fluorescence resonance energy transfer (FRET). In this technique the two hormone proteins are to tag one with the Cyan fluorophore protein (CFP) and the other with the yellow fluorophore protein (YFP). The CFP is excited light of wavelength of 436nm and if the protein- protein interaction does not occur then the excitation of the CFP results in the emission of the light at a wavelength of 475nm on the other hand if the protein- protein interaction occurs perfectly then the CFP and the YFP are brought into close proximity. This leads to the energy transfer fr om the CFP to the nearby YFP. This energy transfer is referred to as FRET. The light emission from the YFP can be detected at a wavelength of 528nm. In this process it will become evident that whether this protein-protein interaction is occurring in the normal cells or in the cancer cells just by comparing their activities (Yuan et al. 2013 pp.1462-1473). Figure 2 Fluorescence resonance energy transfer (FRET) Source: (De Baerdemaeker et al. 2013) Figure 3 Graph of FRET Source: (Google.co.in, 2016) 3. As the ATP synthase of the novel organism is functional and it has essential subunits that are homologous to only 5 essential subunits out of the 8 essential subunits present in the ATP synthase of the all the studied organisms. These subunits are essential for several complex functions. From these findings it can be concluded that the 3 different subunits present in the ATP synthase of the novel organism possess the ability to fulfil all the functional roles of the missing essential subunits. To identify the novel subunits first the proteins of the subunits of both the novel organism and the other studied organisms are to be isolated with the help of gel electrophoresis (Jordan and Dalmasso, 2015). Then taking proteins of the subunits that are similar to the missing essential subunits are digested with the help of the protease enzyme. This type of digestion will generate a unique fragment pattern which will act as finger print which is analysed by mass spectroscopy (Adams, 2012). The mass finger print generated due to mass spectroscopy is then used to find homology between the proteins of the novel organism and the proteins present in the protein sequence data base. To perform this homology identification different web based programs like Mascot ms/ms, MS-Fit and Mascot PMF can be used. Figure 4 Graph of Mass spectroscopy Source: (Google.co.in, 2016) Reference Adams, R.P., 2012. Identification of essential oils by ion trap mass spectroscopy. Academic Press. De Baerdemaeker, T., Lemmens, B., Dotremont, C., Fret, J., Roef, L., Goiris, K. and Diels, L., 2013. Benchmark study on algae harvesting with backwashable submerged flat panel membranes. Bioresource technology, 129, pp.582-591. Google.co.in. (2016). Images of graph of FRET - Google Search. [online] Available at: https://www.google.co.in/search?q=Images+of+graph+of+FRETespv=2tbm=ischimgil=gU7Xvuc-iqk6ZM%253A%253Bnlcc0TO9FWSlXM%253Bhttp%25253A%25252F%25252Fwww.semrock.com%25252Ffret.aspxsource=iupf=mfir=gU7Xvuc-iqk6ZM%253A%252Cnlcc0TO9FWSlXM%252C_usg=__UN4X3UDAeFIZXoPKNuLKluWjuhs%3Dbiw=1366bih=613ved=0ahUKEwi-z8KIpPXPAhWIPI8KHX1SB14QyjcIOQei=ePUOWL6zCYj5vAT9pJ3wBQ#imgrc=gU7Xvuc-iqk6ZM%3A [Accessed 25 Oct. 2016]. Google.co.in. (2016). images of graphs of gelelectrophoresis - Google Search. [online] Available at: https://www.google.co.in/search?q=images+of+graphs+of+gelelectrophoresisespv=2tbm=ischimgil=DeqUs2WJ0lgviM%253A%253Bny3QtfrsQkL2NM%253Bhttps%25253A%25252F%25252Focw.mit.edu%25252Fcourses%25252Fbiological-engineering%25252F20-109-laboratory-fundamentals-in-biological-engineering-fall-2007%25252Flabs%25252Fmod1_2source=iupf=mfir=DeqUs2WJ0lgviM%253A%252Cny3QtfrsQkL2NM%252C_usg=__sGH4UamU30NFaGaqYHsx6MowtJk%3Dbiw=1366bih=613ved=0ahUKEwjDrfzPn_XPAhXIRY8KHWH3AGEQyjcINgei=z_AOWIOKMsiLvQTh7oOIBg#imgrc=DeqUs2WJ0lgviM%3A [Accessed 25 Oct. 2016]. Google.co.in. (2016). images of mass spectroscopy graph of 8 proteins - Google Search. [online] Available at: https://www.google.co.in/search?espv=2biw=1366bih=613tbm=ischsa=1q=images+of+mass+spectroscopy+graph+of+8+proteinsoq=images+of+mass+spectroscopy+graph+of+8+proteinsgs_l=img.3...436785.441114.0.441465.0.0.0.0.0.0.0.0..0.0....0...1c.1.64.img..0.0.0.yHwvTAXUdt8 [Accessed 25 Oct. 2016]. Jordan, K. and Dalmasso, M., 2015. Pulse field gel electrophoresis. Methods in Molecular Biology, 1301. Schaal, B.A. and Anderson, W.W., 2012. 74-3 An outline of techniques for starch gel electrophoresis of enzymes from the American Oyster Crassostrea virginica Gmelin. Sugimoto, M., Kawakami, M., Robert, M., Soga, T. and Tomita, M., 2012. Bioinformatics tools for mass spectroscopy-based metabolomic data processing and analysis. Current bioinformatics, 7(1), pp.96-108. Yuan, L., Lin, W., Zheng, K. and Zhu, S., 2013. FRET-based small-molecule fluorescent probes: rational design and bioimaging applications. Accounts of chemical research, 46(7), pp.1462-1473.